Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | APLNR | P35414 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083109 | 0.77 | KDM4E (0.37) | HSD17B10ALDH1A1MAPTMAPK1GFER | |
| SCHEMBL8361535 | 0.73 | ALDH1A1 (0.44) | HSD17B10ALDH1A1L3MBTL1MAPTMAPK1 | |
| SCHEMBL16479314 | 0.70 | KDM4E (0.42) | HSD17B10ALDH1A1L3MBTL1KDM4EKDM4C | |
| SCHEMBL14409742 | 0.69 | MEN1 (0.46) | POLBALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL2592749 | 0.68 | CA12 (0.67) | ALDH1A1MAPK1KDM4ETSHRHTT | |
| SCHEMBL8429886 | 0.67 | MAPT (0.60) | HSD17B10POLBALDH1A1MAPTNPSR1 | |
| SCHEMBL31172821 | 0.67 | APLNR (0.66) | HSD17B10ALDH1A1MAPTCYP3A4MEN1 | |
| SCHEMBL805138 | 0.67 | APLNR (0.66) | HSD17B10ALDH1A1MAPTCYP3A4MEN1 | |
| SCHEMBL10187102 | 0.67 | L3MBTL1 (0.60) | HSD17B10POLBALDH1A1L3MBTL1MAPT | |
| SCHEMBL10562771 | 0.67 | ALDH1A1 (0.44) | HSD17B10POLBALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1778686-A2 | TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS | Pfizer Limited (GB) | 2007-05-02 | — | — | EP | disclosed |
| WO-2006018718-A2 | TRIAZOLOPYRIDINYLSULFANYL DERIVATIVES AS P38 MAP KINASE INHIBITORS | PFIZER LIMITED (GB) | 2006-02-23 | — | — | WO | disclosed |