Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | ABCB1 | P08183 | 3/20 | 0.36 |
| ▸ | CASR | P41180 | 2/20 | 0.35 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5308706 | 1.00 | MEN1 (0.37) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5311481 | 0.93 | ALDH1A1 (0.40) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5311478 | 0.93 | ALDH1A1 (0.40) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5310553 | 0.93 | MEN1 (0.40) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5310556 | 0.93 | MEN1 (0.40) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5310510 | 0.91 | ALDH1A1 (0.40) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5310508 | 0.91 | ALDH1A1 (0.40) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5311122 | 0.90 | ALDH1A1 (0.42) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5311126 | 0.90 | ALDH1A1 (0.42) | MEN1ALDH1A1LMNAHTTKMT2A | |
| SCHEMBL5307926 | 0.89 | ALDH1A1 (0.38) | MEN1ALDH1A1LMNAHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |