Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | CASP7 | P55210 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5310510 | 1.00 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5310553 | 0.93 | MEN1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5310556 | 0.93 | MEN1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5308706 | 0.91 | MEN1 (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5308705 | 0.91 | MEN1 (0.37) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5307926 | 0.90 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5307927 | 0.90 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5315684 | 0.90 | MEN1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5315689 | 0.90 | MEN1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA | |
| SCHEMBL5311478 | 0.88 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |