Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | MGLL | Q99685 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.36 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311481 | 1.00 | ALDH1A1 (0.40) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5311122 | 0.95 | ALDH1A1 (0.42) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5311126 | 0.95 | ALDH1A1 (0.42) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5314095 | 0.94 | LMNA (0.43) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5314097 | 0.94 | LMNA (0.43) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5308705 | 0.93 | MEN1 (0.37) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5308706 | 0.93 | MEN1 (0.37) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5313185 | 0.93 | ALDH1A1 (0.40) | ALDH1A1LMNAHTTENPP2FAAH | |
| SCHEMBL5313189 | 0.93 | ALDH1A1 (0.40) | ALDH1A1LMNAHTTENPP2FAAH | |
| SCHEMBL5315684 | 0.93 | MEN1 (0.40) | ALDH1A1LMNAMEN1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |