Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACMSD | Q8TDX5 | 6/20 | 0.72 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.72 |
| ▸ | HNF4A | P41235 | 2/20 | 0.72 |
| ▸ | DHFR | P00374 | 1/20 | 0.72 |
| ▸ | CHUK | O15111 | 4/20 | 0.69 |
| ▸ | IKBKB | O14920 | 4/20 | 0.68 |
| ▸ | GSTA1 | P08263 | 1/20 | 0.66 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.55 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7022773 | 0.85 | ACMSD (0.72) | ACMSDMCL1HNF4ADHFRCHUK | |
| SCHEMBL5724394 | 0.84 | BCAT2 (0.61) | ACMSDMCL1HNF4ADHFRCHUK | |
| SCHEMBL30595681 | 0.84 | IKBKB (0.72) | ACMSDMCL1HNF4ADHFRCHUK | |
| SCHEMBL9273036 | 0.84 | ACMSD (1.00) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL29759663 | 0.84 | ACMSD (1.00) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL23143193 | 0.84 | ACMSD (1.00) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL5332435 | 0.84 | IKBKB (0.72) | ACMSDMCL1HNF4ADHFRCHUK | |
| SCHEMBL330602 | 0.84 | ACMSD (1.00) | ACMSDMCL1HNF4ADHFRGSTA1 | |
| SCHEMBL3691427 | 0.83 | CHUK (0.67) | ACMSDMCL1HNF4ADHFRCHUK | |
| SCHEMBL5302317 | 0.83 | CHUK (0.67) | ACMSDMCL1HNF4ADHFRCHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014020350-A1 | PAR2 RECEPTOR ANTAGONISTS | PROXIMAGEN LIMITED (GB) | 2014-02-06 | — | — | WO | disclosed |
| WO-2014020351-A1 | RECEPTOR ANTAGONISTS | PROXIMAGEN LIMITED (GB) | 2014-02-06 | — | — | WO | disclosed |
| WO-2007025575-A1 | O-HYDROXY- AND O-AMINO BENZAMIDE DERIVATIVES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |
| WO-2007025575-A1 | O-HYDROXY- AND O-AMINO BENZAMIDE DERIVATIVES AS IKK2 INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-08 | — | — | WO | disclosed |
| EP-0221346-B1 | (N-SUBSTITUTED-2-HYDROXY) BENZAMIDES AND N-SUBSTITUTED-2-HYDROXY-ALPHA-OXO-BENZENEACETAMIDES AND PHARMACEUTICAL COMPOSITIONS THEREOF HAVING ACTIVITY AS MODULATORS OF THE ARACHIDONIC ACID CASCADE | WARNER-LAMBERT COMPANY (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4939133-A | N-substituted-2-hydroxy-α-oxo-benzeneacetamides and pharmaceutical compositions having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1990-07-03 | — | — | US | disclosed |
| EP-0221346-A1 | (N-substituted-2-hydroxy) benzamides and N-substituted-2-hydroxy-alpha-oxo-benzeneacetamides and pharmaceutical compositions thereof having activity as modulators of the arachidonic acid cascade | WARNER-LAMBERT COMPANY (US) | 1987-05-13 | — | — | EP | disclosed |
| US-4140769-A | ANALGESICS | MILES LABORATORIES, INC. (US) | 1979-02-20 | — | — | US | disclosed |