Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.66 |
| ▸ | LMNA | P02545 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | ALPG | P10696 | 1/20 | 0.62 |
| ▸ | PKM | P14618 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 1/20 | 0.47 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15060715 | 0.85 | KAT2B (0.61) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL29719483 | 0.84 | LMNA (0.50) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL18496266 | 0.84 | LMNA (0.50) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL12210037 | 0.84 | LMNA (0.50) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL11048929 | 0.82 | MAPT (0.65) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL10799657 | 0.82 | MAPT (0.69) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL741469 | 0.81 | MAPT (0.70) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL2016758 | 0.81 | MAPT (0.63) | MAPTLMNASMN1; SMN2TDP1ALPG | |
| SCHEMBL6595723 | 0.80 | MAPT (0.65) | MAPTLMNASMN1; SMN2ALDH1A1L3MBTL1 | |
| SCHEMBL7767318 | 0.80 | MAPT (0.62) | MAPTLMNASMN1; SMN2TDP1ALPG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007020521-A1 | PYRIDOYRAZINONES AS PDE-5 INHIBITORS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2007-02-22 | — | — | WO | disclosed |