Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.30 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21381606 | 0.80 | MAPK1 (0.37) | MAPTCTSA | |
| SCHEMBL5306377 | 0.78 | CDK2 (0.39) | CTSA | |
| SCHEMBL9988882 | 0.77 | LMNA (0.51) | MAPT | |
| SCHEMBL2580431 | 0.76 | ALDH1A1 (0.38) | MAPTCTSA | |
| SCHEMBL2654654 | 0.75 | MAPT (0.39) | MAPT | |
| SCHEMBL21381538 | 0.74 | AKR1C3 (0.37) | CTSA | |
| SCHEMBL2645148 | 0.73 | MAPT (0.37) | MAPT | |
| SCHEMBL5772798 | 0.73 | MAPT (0.35) | MAPT | |
| SCHEMBL26122997 | 0.72 | MAPK1 (0.39) | MAPTCTSA | |
| SCHEMBL12985769 | 0.72 | MAPT (0.39) | MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007035153-A1 | NOVEL PROCESS FOR THE PREPARATION OF 6-METHYL-PYRAZIN-2-YLAMINE | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007035154-A1 | NOVEL N-PYRAZINIL-PHENYLSULFONAMIDE DERIVATIVES AS CHEMOKINE RECEPTOR MODULATORS FOR USE IN THE TREATMENT OF ASTHMA | ASTRAZENECA AB (SE) | 2007-03-29 | — | — | WO | disclosed |