Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | XBP1 | P17861 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.32 |
| ▸ | STK17B | O94768 | 1/20 | 0.31 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.31 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.31 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.31 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL940332 | 0.80 | MAPK1 (0.40) | MAPTALDH1A1MAPK1GABRA1GABRG2 | |
| SCHEMBL18335086 | 0.78 | MAPK1 (0.38) | MAPTMAPK1NPSR1HSD17B10GABRA1 | |
| SCHEMBL4534445 | 0.77 | MAPT (0.37) | MAPTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL17476583 | 0.77 | MAPT (0.40) | MAPTALDH1A1NPC1TP53HTT | |
| SCHEMBL5772792 | 0.76 | MEN1 (0.44) | MAPTALDH1A1TDP1NPC1TP53 | |
| SCHEMBL5309259 | 0.73 | MAPT (0.36) | MAPT | |
| SCHEMBL12985302 | 0.72 | MAPT (0.38) | MAPTGABRA1GABRG2GABRB3GABRA5 | |
| SCHEMBL15142139 | 0.72 | ALDH1A1 (0.36) | MAPTALDH1A1TDP1TP53MAPK1 | |
| SCHEMBL2654654 | 0.71 | MAPT (0.39) | MAPTALDH1A1NPC1STING1MEN1 | |
| SCHEMBL7691831 | 0.71 | MAPT (0.43) | MAPTALDH1A1NPC1TP53HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006066899-A1 | NOVEL THROMBIN INHIBITORS | SANTHERA PHARMACEUTICALS (SCHWEIZ) AG (CH) | 2006-06-29 | — | — | WO | disclosed |
| EP-1674464-A1 | Novel thrombin inhibitors | Santhera Pharmaceuticals (Schweiz) GmbH (CH) | 2006-06-28 | — | — | EP | disclosed |