Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.58 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 3/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL7752847 | 1.00 | CA4 (0.58) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL28087127 | 0.96 | CA4 (0.54) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL27695617 | 0.96 | CA4 (0.54) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL5655343 | 0.96 | CA4 (0.54) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL28587804 | 0.96 | CA4 (0.54) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL23363863 | 0.96 | CA4 (0.54) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL9093117 | 0.96 | CA4 (0.54) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL9004283 | 0.95 | CA4 (0.50) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL7996596 | 0.95 | CA4 (0.50) | CA4FAHD1MEN1LDHABLM | |
| Bicarbonate SCHEMBL6704237 | 0.95 | CA4 (0.64) | CA4FAHD1MEN1LDHABLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106064826-A | Method and equipment for recovering copper resources by using circuit board acidic etching waste liquid | 东莞市广华化工有限公司 | 2016-11-02 | — | — | CN | claimed |
| US-20070078266-A1 | Novel mercaptobenzimidazole substituted benzotriazole UV absorber and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2007-04-05 | — | — | US | claimed |
| WO-2007036948-A1 | NOVEL MERCAPTOBENZIMIDAZOLE SUBSTITUTED BENZOTRIAZOLE UV ABSORBER AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2007-04-05 | — | — | WO | claimed |
| CN-106064826-A | Method and equipment for recovering copper resources by using circuit board acidic etching waste liquid | 东莞市广华化工有限公司 | 2016-11-02 | — | — | CN | disclosed |
| CN-100512801-C | Compound isatis root effervescent tablet and its preparation method | GUIZHOU PROV BAILING ENTPR GRO (CN) | 2009-07-15 | — | — | CN | disclosed |
| WO-2007036948-A1 | NOVEL MERCAPTOBENZIMIDAZOLE SUBSTITUTED BENZOTRIAZOLE UV ABSORBER AND PROCESS FOR PREPARATION THEREOF | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2007-04-05 | — | — | WO | disclosed |
| US-20070078266-A1 | Novel mercaptobenzimidazole substituted benzotriazole UV absorber and process for preparation thereof | COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH (IN) | 2007-04-05 | — | — | US | disclosed |
| CN-1861106-A | Compound isatis root effervescent tablet and its prepn. method | BAILING ENTPR GROUP PHARMACEUT (CN) | 2006-11-15 | — | — | CN | disclosed |
| JP-2004315458-A | METHOD FOR REFINING EPISULFIDE COMPOSITION | MITSUI CHEMICALS INC | 2004-11-11 | — | — | JP | disclosed |
| EP-1254107-A1 | BENZOIC ACID ESTERS, AND LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GmbH (DE) | 2002-11-06 | — | — | EP | disclosed |
| WO-2001058858-A1 | BENZOIC ACID ESTERS, AND LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2001-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070078266-A1 | Novel mercaptobenzimidazole substituted benzotriazole UV absorber and process for preparation thereof | SULT1A1, SULT2A1, CYP1A1 | CA4 3139/4885FAHD1 4511/4885MEN1 1858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.