Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 6/20 | 0.64 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.64 |
| ▸ | CA1 | P00915 | 3/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LDHA | P00338 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL59690 | 1.00 | CA4 (0.64) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL5309573 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL28890785 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL9442722 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL7752847 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL28537604 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL9133995 | 0.95 | CA4 (0.58) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL18042414 | 0.95 | CA1 (0.56) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL2970314 | 0.95 | CA1 (0.56) | CA4FAHD1CA1CA2MEN1 | |
| Bicarbonate SCHEMBL11309619 | 0.95 | CA1 (0.56) | CA4FAHD1CA1CA2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2004313962-A | PRODUCTION METHOD OF CARBON DIOXIDE ABSORBENT MATERIAL | TOSHIBA CERAMICS CO LTD | 2004-11-11 | — | — | JP | disclosed |