Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 16/20 | 0.64 |
| ▸ | CA1 | P00915 | 15/20 | 0.64 |
| ▸ | CA9 | Q16790 | 14/20 | 0.64 |
| ▸ | CA12 | O43570 | 10/20 | 0.64 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.64 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.64 |
| ▸ | CA7 | P43166 | 4/20 | 0.60 |
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5309725 | 1.00 | CA2 (0.64) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL11406653 | 0.82 | GRIN2D (0.53) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL11406654 | 0.82 | GRIN2D (0.53) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL5311683 | 0.78 | PTGS2 (1.00) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL5312313 | 0.78 | PTGS2 (1.00) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL5311687 | 0.78 | PTGS2 (1.00) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL5312314 | 0.78 | PTGS2 (1.00) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL19967365 | 0.76 | GRIN2D (0.47) | CA2CA1CA9CA12PTGS2 | |
| SCHEMBL11404562 | 0.76 | NFE2L2 (0.52) | PTGS2ACHE | |
| SCHEMBL11404558 | 0.76 | NFE2L2 (0.52) | PTGS2ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799823-B1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | DAIICHI SANKYO CO LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-RE39420-E1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-12-05 | — | — | US | disclosed |
| US-5908858-A | OSTEOPOROSIS; LEUKOTRIENE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |