Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 11/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5312353 | 0.93 | CASR (0.54) | CASRPOLBRXFP1 | |
| SCHEMBL5310910 | 0.91 | CASR (0.52) | CASRLMNASMN1; SMN2POLBMEN1 | |
| SCHEMBL5310323 | 0.91 | CASR (0.52) | CASRSMN1; SMN2POLBMEN1HPGD | |
| SCHEMBL5311393 | 0.89 | CASR (0.50) | CASRPOLBMEN1KMT2ARXFP1 | |
| SCHEMBL5309926 | 0.88 | CASR (0.49) | CASRSMN1; SMN2MEN1KMT2ARXFP1 | |
| SCHEMBL5313301 | 0.88 | CASR (0.49) | CASRSMN1; SMN2POLBMEN1KMT2A | |
| SCHEMBL5309871 | 0.88 | CASR (0.49) | CASRPOLBHPGDRXFP1KDM4E | |
| SCHEMBL5307893 | 0.88 | THRB (0.41) | CASRLMNASMN1; SMN2POLBMEN1 | |
| SCHEMBL5307948 | 0.88 | CASR (0.49) | CASRPOLBHPGDKDM4EALDH1A1 | |
| SCHEMBL5310145 | 0.86 | CASR (0.51) | CASRHPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |