Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 9/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315681 | 0.93 | CASR (0.49) | CASRGAAPOLB | |
| SCHEMBL5307948 | 0.93 | CASR (0.49) | CASRGAAPOLBAURKAAURKB | |
| SCHEMBL5312353 | 0.92 | CASR (0.54) | CASRGAAPOLB | |
| SCHEMBL5310910 | 0.91 | CASR (0.52) | CASRMEN1KMT2ASMN1; SMN2POLB | |
| SCHEMBL5309465 | 0.90 | CASR (0.47) | CASRMAPTGAAKMT2ASMN1; SMN2 | |
| SCHEMBL5309931 | 0.88 | CASR (0.47) | CASRGAAPOLB | |
| SCHEMBL14542007 | 0.88 | MAPT (0.43) | CASRMAPTCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5310310 | 0.88 | CASR (0.50) | CASRMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5310323 | 0.87 | CASR (0.52) | CASRMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL5310639 | 0.87 | CASR (0.48) | CASRCYP1A2CYP3A4CYP2D6CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | claimed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |