Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | TSHR | P16473 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.62 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.60 |
| ▸ | NPC1 | O15118 | 4/20 | 0.60 |
| ▸ | MAPT | P10636 | 4/20 | 0.60 |
| ▸ | RAB9A | P51151 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | STAT1 | P42224 | 1/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.60 |
| ▸ | ACP1 | P24666 | 1/20 | 0.60 |
| ▸ | CA2 | P00918 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11875528 | 0.88 | RIPK1 (0.62) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL3753095 | 0.85 | DYRK1A (0.71) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL27566837 | 0.83 | DYRK1A (0.76) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL29974725 | 0.82 | DYRK1A (0.67) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL11157181 | 0.82 | DYRK1A (0.64) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL28878443 | 0.82 | DYRK1A (0.67) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL5310554 | 0.82 | RIPK1 (0.73) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL23510629 | 0.81 | DYRK1A (0.66) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL31527831 | 0.81 | DYRK1A (0.62) | DYRK1AALDH1A1TDP1CYP3A4TSHR | |
| SCHEMBL16732745 | 0.81 | DYRK1A (0.78) | DYRK1AALDH1A1KMT2ASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160175303-A1 | SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-06-23 | — | — | US | claimed |
| US-20120095021-A1 | SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2012-04-19 | — | — | US | claimed |
| US-9949970-B2 | Synthesis of new benzothiazole derivatives as potential anti-tubercular agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-04-24 | — | — | US | disclosed |
| US-9932300-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2018-04-03 | — | — | US | disclosed |
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE | 2016-11-03 | — | — | US | disclosed |
| US-9421211-B2 | N,N′-diarylurea compounds and N,N′-diarylthiourea compounds as inhibitors of translation initiation | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-08-23 | — | — | US | disclosed |
| US-20160175303-A1 | SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-06-23 | — | — | US | disclosed |
| US-9273039-B2 | Synthesis of new benzothiazole derivatives as potential anti-tubercular agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-03-01 | — | — | US | disclosed |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2012-05-10 | — | — | US | disclosed |
| US-20120101278-A1 | PROCESS FOR PRODUCING BIARYL COMPOUND | HAGIYA KOJI (JP) | 2012-04-26 | — | — | US | disclosed |
| US-20120095021-A1 | SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2012-04-19 | — | — | US | disclosed |
| US-20050096471-A1 | Process for producing biaryl compound | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2005-05-05 | — | — | US | disclosed |
| EP-1473286-A1 | PROCESS FOR PRODUCING BIARYL COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2004-11-03 | — | — | EP | disclosed |
| US-5445854-A | A cured epoxy resins having glycidyl aromatic or heterocylic hydrazone monomer; high glass transition temperature, stability | THE DOW CHEMICAL COMPANY (US) | 1995-08-29 | — | — | US | disclosed |
| US-5288816-A | High glass transition temperature; stability | THE DOW CHEMICAL COMPANY (US) | 1994-02-22 | — | — | US | disclosed |
| WO-1994003557-A1 | NOVEL NONLINEAR OPTICAL AMINOARYL HYDRAZONES AND NONLINEAR OPTICAL POLYMERS THEREOF | THE DOW CHEMICAL COMPANY (US) | 1994-02-17 | — | — | WO | disclosed |
| US-5208299-A | Optical polymers for electronic processors and integrated circuits | THE DOW CHEMICAL COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| US-4837308-A | Process for the preparation of azo compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1989-06-06 | — | — | US | disclosed |
| EP-0201892-B1 | METHOD OF MAKING AZO COMPOUNDS | BAYER AG (DE) | 1989-03-08 | — | — | EP | disclosed |
| EP-0201892-A1 | Method of making azo compounds | BAYER AG (DE) | 1986-11-20 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160318857-A1 | N,N'-Diarylurea Compounds and N,N'-Diarylthiourea Compounds as Inhibitors of Translation Initiation | NSUN2, EIF2AK2, RNGTT | DYRK1A 3593/4885ALDH1A1 3464/4885TDP1 442/4885 |
| US-20120101278-A1 | PROCESS FOR PRODUCING BIARYL COMPOUND | PPOX, CAT, TYR | DYRK1A 1872/4885ALDH1A1 1191/4885TDP1 4617/4885 |
| US-20160175303-A1 | SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | TST, TBCA, SDHA | DYRK1A 4405/4885ALDH1A1 782/4885TDP1 2566/4885 |
| US-20120095021-A1 | SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | TST, SDHB, SDHA | DYRK1A 4011/4885ALDH1A1 1613/4885TDP1 1091/4885 |
| US-20050096471-A1 | Process for producing biaryl compound | PPOX, CAT, TYR | DYRK1A 1872/4885ALDH1A1 1191/4885TDP1 4617/4885 |
| US-20120115915-A1 | N,N'-DIARYLUREA COMPOUNDS AND N,N'-DIARYLTHIOUREA COMPOUNDS AS INHIBITORS OF TRANSLATION INITIATION | NSUN2, EIF2AK2, RNGTT | DYRK1A 3593/4885ALDH1A1 3464/4885TDP1 442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.