SCHEMBL531060

SCHEMBL531060

CCCCCCNC(CC=O)c1cnc2ccccc2c1

nearest known ligand 0.41

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
TRPV1 Q8NER1 12/20 0.41
KMT2A Q03164 3/20 0.39
MEN1 O00255 2/20 0.39
KDM4E B2RXH2 1/20 0.39
SMN1; SMN2 Q16637 1/20 0.39
TLR8 Q9NR97 2/20 0.37
HDAC3 O15379 1/20 0.36
HDAC4 P56524 1/20 0.36
HDAC1 Q13547 1/20 0.36
HDAC7 Q8WUI4 1/20 0.36
HDAC2 Q92769 1/20 0.36
HDAC10 Q969S8 1/20 0.36
HDAC11 Q96DB2 1/20 0.36
HDAC8 Q9BY41 1/20 0.36
HDAC6 Q9UBN7 1/20 0.36
HDAC9 Q9UKV0 1/20 0.36
HDAC5 Q9UQL6 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12505086 0.85 TRPV1 (0.43) TRPV1KMT2AMEN1KDM4ESMN1; SMN2
SCHEMBL531058 0.74 NAAA (0.50) TRPV1HDAC3HDAC4HDAC1HDAC7
SCHEMBL14357517 0.71 TLR8 (0.44) TRPV1KMT2AMEN1SMN1; SMN2TLR8
SCHEMBL531061 0.71 TRPV1 (0.49) TRPV1HDAC3HDAC1HDAC2
SCHEMBL530808 0.71 CYP1A2 (0.45) KMT2AKDM4ESMN1; SMN2
SCHEMBL29459383 0.69 SMN1; SMN2 (0.41) KMT2AMEN1KDM4ESMN1; SMN2TLR8
SCHEMBL28673131 0.69 SMN1; SMN2 (0.41) KMT2AMEN1KDM4ESMN1; SMN2TLR8
SCHEMBL22210843 0.69 MEN1 (0.45) TRPV1KMT2AMEN1SMN1; SMN2TLR8
SCHEMBL12505087 0.68 TRPV1 (0.51) TRPV1HDAC3HDAC1HDAC2
SCHEMBL30445473 0.68 TRPV1 (0.46) TRPV1KMT2AMEN1TLR8HDAC3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2597955-A1 QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME OncoTherapy Science, Inc. (JP) 2013-06-05 EP disclosed
WO-2012016082-A1 QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME ONCOTHERAPY SCIENCE, INC. (JP) 2012-02-02 WO disclosed