SCHEMBL5311345

SCHEMBL5311345

Cc1ccc(-c2ccc(-c3cn4c(n3)CCC(C(N)=O)C4)cc2)cc1C

nearest known ligand 0.41

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
WDR5 P61964 11/20 0.41
LMNA P02545 4/20 0.40
ALDH1A1 P00352 4/20 0.40
NPC1 O15118 4/20 0.39
RAB9A P51151 4/20 0.39
HTT P42858 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
KDM4E B2RXH2 1/20 0.38
GAA P10253 1/20 0.36
KMT2A Q03164 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5375882 0.86 NPC1 (0.41) WDR5LMNAALDH1A1NPC1RAB9A
SCHEMBL5306345 0.80 LMNA (0.41) WDR5LMNAALDH1A1NPC1RAB9A
SCHEMBL5308583 0.80 LMNA (0.41) WDR5LMNAALDH1A1NPC1RAB9A
SCHEMBL20337613 0.78 WDR5 (0.44) WDR5LMNAALDH1A1
SCHEMBL5329805 0.77 WDR5 (0.39) WDR5LMNAALDH1A1
SCHEMBL5303254 0.76 MAPK14 (0.38) WDR5LMNAALDH1A1KDM4E
SCHEMBL5372799 0.74 WDR5 (0.40) WDR5ALDH1A1KDM4EGAA
SCHEMBL18281441 0.74 WDR5 (0.38) WDR5LMNAALDH1A1SMN1; SMN2
SCHEMBL5306661 0.74 WDR5 (0.40) WDR5LMNAALDH1A1KDM4E
SCHEMBL18281430 0.74 MAPK14 (0.46) WDR5LMNAALDH1A1NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007034282-A2 DIARYL-IMIDAZOLE COMPOUNDS CONDENSED WITH A HETEROCYCLE AS C3A RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2007-03-29 WO claimed
US-10933049-B2 Mobilizing agents and uses therefor THE UNIVERSITY OF QUEENSLAND (AU) 2021-03-02 US disclosed
US-20180185328-A1 MOBILIZING AGENTS AND USES THEREFOR THE UNIVERSITY OF QUEENSLAND (AU) 2018-07-05 US disclosed
EP-3302710-A1 MOBILIZING AGENTS AND USES THEREFOR The University of Queensland (AU) 2018-04-11 EP disclosed
WO-2016191811-A1 MOBILIZING AGENTS AND USES THEREFOR THE UNIVERSITY OF QUEENSLAND (AU) 2016-12-08 WO disclosed
WO-2007034282-A2 DIARYL-IMIDAZOLE COMPOUNDS CONDENSED WITH A HETEROCYCLE AS C3A RECEPTOR ANTAGONISTS PFIZER PRODUCTS INC. (US) 2007-03-29 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180185328-A1 MOBILIZING AGENTS AND USES THEREFOR C3AR1, CSF3R, C5AR1 WDR5 2932/4885LMNA 3889/4885ALDH1A1 2492/4885
US-10933049-B2 Mobilizing agents and uses therefor C3AR1, CSF3R, C5AR1 WDR5 2932/4885LMNA 3889/4885ALDH1A1 2492/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.