Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.50 |
| ▸ | CHAT | P28329 | 5/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4916043 | 0.92 | RXRA (0.47) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL4626591 | 0.87 | RXRA (0.57) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL29399914 | 0.87 | RXRA (0.57) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL4626594 | 0.87 | RXRA (0.57) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL27495890 | 0.85 | RXRA (0.55) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL27493524 | 0.85 | RXRA (0.55) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL27525379 | 0.85 | RXRA (0.55) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL10706694 | 0.82 | CHAT (0.62) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL10706687 | 0.82 | CHAT (0.62) | RXRACHATHDAC8HDAC6MTNR1A | |
| SCHEMBL10706700 | 0.82 | CHAT (0.62) | RXRACHATHDAC8HDAC6MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1610126-B1 | A system for determining the electrical potential across a membrane | UNIV CALIFORNIA (US) | 2014-04-30 | — | — | EP | disclosed |
| EP-1409456-B1 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | UNIV CALIFORNIA (US) | 2012-02-08 | — | — | EP | disclosed |
| EP-0977035-B2 | A system for determining the electrical potential across a membrane | UNIV CALIFORNIA (US) | 2010-07-21 | — | — | EP | disclosed |
| US-7687282-B2 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2010-03-30 | — | — | US | disclosed |
| US-7173130-B2 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-02-06 | — | — | US | disclosed |
| US-20070026384-A1 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2007-02-01 | — | — | US | disclosed |
| US-7118899-B2 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-10-10 | — | — | US | disclosed |
| US-7115401-B2 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-10-03 | — | — | US | disclosed |
| US-7087416-B2 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2006-08-08 | — | — | US | disclosed |
| EP-1678185-A1 | 2,3-DIHYDRO-6-NITROIMIDAZO [2,1-B] OXAZOLE COMPOUNDS FOR THE TREATMENT OF TUBERCULOSIS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2006-07-12 | — | — | EP | disclosed |
| US-20030129670-A1 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2003-07-10 | — | — | US | disclosed |
| US-20020164577-A1 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-11-07 | — | — | US | disclosed |
| US-20020137201-A1 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2002-09-26 | — | — | US | disclosed |
| US-6342379-B1 | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-01-29 | — | — | US | disclosed |
| WO-2001042211-A2 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2001-06-14 | — | — | WO | disclosed |
| US-6107066-A | Detection of transmembrane potentials by optical methods | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-08-22 | — | — | US | disclosed |
| EP-0977035-A2 | A system for determining the electrical potential across a membrane | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2000-02-02 | — | — | EP | disclosed |
| EP-0834074-B1 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | UNIV CALIFORNIA (US) | 1999-11-03 | — | — | EP | disclosed |
| EP-0834074-A1 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-04-08 | — | — | EP | disclosed |
| WO-1996041166-A2 | DETECTION OF TRANSMEMBRANE POTENTIALS BY OPTICAL METHODS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-12-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070026384-A1 | Detection of transmembrane potentials by optical methods | MBOAT1, TRPM4, NME4 | RXRA 620/4885CHAT 2363/4885HDAC8 4431/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.