Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 8/20 | 0.43 |
| ▸ | CASR | P41180 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HTR7 | P34969 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311052 | 0.91 | CASR (0.43) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5307935 | 0.89 | TP53 (0.44) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5311327 | 0.87 | CASR (0.52) | GNRHRCASR | |
| SCHEMBL5311895 | 0.87 | GNRHR (0.42) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5308342 | 0.86 | POLB (0.48) | GNRHRCASRKDM4EMAPT | |
| SCHEMBL5312354 | 0.86 | TP53 (0.42) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5316049 | 0.85 | HTR7 (0.43) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5308608 | 0.85 | CHRM1 (0.41) | GNRHRCASRKDM4EL3MBTL1TAAR1 | |
| SCHEMBL5307893 | 0.85 | THRB (0.41) | GNRHRCASRKDM4EMAPT | |
| SCHEMBL14542013 | 0.85 | MAPT (0.40) | GNRHRCASRKDM4EL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |