Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 8/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.32 |
| ▸ | KDR | P35968 | 3/20 | 0.31 |
| ▸ | BRAF | P15056 | 3/20 | 0.31 |
| ▸ | RAF1 | P04049 | 1/20 | 0.30 |
| ▸ | RXRA | P19793 | 1/20 | 0.30 |
| ▸ | RXRB | P28702 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311529 | 0.88 | LCK (0.39) | LCKIRAK4KDM4EMAPTNR3C2 | |
| SCHEMBL14530871 | 0.88 | LCK (0.39) | LCKIRAK4KDM4EMAPTNR3C2 | |
| SCHEMBL5311989 | 0.87 | LCK (0.37) | LCKIRAK4KDM4EMAPTKDR | |
| SCHEMBL5313272 | 0.87 | LCK (0.38) | LCKIRAK4KDM4EMAPTKDR | |
| SCHEMBL5312890 | 0.86 | LCK (0.38) | LCKIRAK4KDM4EMAPTNR3C2 | |
| SCHEMBL5309870 | 0.86 | LCK (0.37) | LCKIRAK4KDM4EMAPTNR3C2 | |
| SCHEMBL5316887 | 0.86 | LCK (0.38) | LCKIRAK4KDM4EMAPTNR3C2 | |
| SCHEMBL5315891 | 0.86 | LCK (0.35) | LCKIRAK4NR3C2 | |
| SCHEMBL5312823 | 0.85 | LCK (0.35) | LCKIRAK4KDM4EMAPTKDR | |
| SCHEMBL5312033 | 0.85 | LCK (0.36) | LCKIRAK4NR3C2KDRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | claimed |
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | disclosed |
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | disclosed |