Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | WNT3A | P56704 | 3/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RIOK2 | Q9BVS4 | 2/20 | 0.33 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.33 |
| ▸ | GSK3A | P49840 | 1/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.33 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.33 |
| ▸ | SNRK | Q9NRH2 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14530871 | 0.91 | LCK (0.39) | LCKIRAK4BRAFKDRMAPT | |
| SCHEMBL5311529 | 0.91 | LCK (0.39) | LCKIRAK4BRAFRAF1KDR | |
| SCHEMBL5312732 | 0.90 | LCK (0.37) | LCKIRAK4KDRMEN1NPC1 | |
| SCHEMBL5311989 | 0.90 | LCK (0.37) | LCKIRAK4CSNK1DWNT3AKDR | |
| SCHEMBL5313272 | 0.88 | LCK (0.38) | LCKIRAK4BRAFRAF1KDR | |
| SCHEMBL5312823 | 0.88 | LCK (0.35) | LCKIRAK4CSNK1DWNT3AKDR | |
| SCHEMBL5316887 | 0.87 | LCK (0.38) | LCKIRAK4BRAFKDRMAPT | |
| SCHEMBL5312821 | 0.87 | LCK (0.35) | LCKIRAK4BRAFCSNK1DWNT3A | |
| SCHEMBL5314719 | 0.87 | ALDH1A1 (0.35) | LCKIRAK4KDRMAPTMEN1 | |
| SCHEMBL5312746 | 0.86 | LCK (0.37) | LCKIRAK4BRAFRAF1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | claimed |
| WO-2007058482-A1 | NOVEL INHIBITORS OF PROTEIN KINASE | LG LIFE SCIENCES, LTD. (KR) | 2007-05-24 | — | — | WO | disclosed |