Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5329820 | 0.89 | ADORA2A (0.41) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL5313105 | 0.88 | SCD (0.44) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL5307458 | 0.83 | DPP4 (0.41) | L3MBTL1ALDH1A1 | |
| SCHEMBL5313055 | 0.81 | KDM4E (0.52) | NPC1RAB9ASMN1; SMN2L3MBTL1KMT2A | |
| SCHEMBL5311601 | 0.81 | PTGES (0.44) | SMN1; SMN2L3MBTL1KMT2AKDM4ETDP1 | |
| SCHEMBL5307816 | 0.81 | HCRTR1 (0.43) | — | |
| SCHEMBL5308057 | 0.80 | PTGES (0.45) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL5313775 | 0.79 | MEN1 (0.39) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL5314274 | 0.79 | MEN1 (0.39) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL5335811 | 0.77 | MEN1 (0.40) | NPC1RAB9ASMN1; SMN2L3MBTL1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044085-A2 | HETEROARYL COMPOUNDS AND THEIR USES AS THERAPEUTIC AGENTS | XENON PHARMACEUTICALS INC. (CA) | 2007-04-19 | — | — | WO | disclosed |