Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CASR | P41180 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313301 | 0.88 | CASR (0.49) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5313082 | 0.85 | LMNA (0.45) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5307935 | 0.83 | TP53 (0.44) | MAPTCASRPOLBALDH1A1TP53 | |
| SCHEMBL5312354 | 0.82 | TP53 (0.42) | MAPTCYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL5307893 | 0.81 | THRB (0.41) | MAPTCASRPOLBALDH1A1TP53 | |
| SCHEMBL5315681 | 0.81 | CASR (0.49) | CASRGAAPOLBALDH1A1PKM | |
| SCHEMBL5307948 | 0.81 | CASR (0.49) | CASRGAAPOLBAURKAAURKB | |
| SCHEMBL5312353 | 0.79 | CASR (0.54) | CASRGAAPOLB | |
| SCHEMBL5308342 | 0.79 | POLB (0.48) | MAPTCASRPOLBALDH1A1TP53 | |
| SCHEMBL5310910 | 0.79 | CASR (0.52) | CASRPOLBALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007044796-A2 | PYRIDAZINONE COMPOUNDS AS CALCILYTICS | NPS PHARMACEUTICALS, INC. (US) | 2007-04-19 | — | — | WO | disclosed |