SCHEMBL5313829

SCHEMBL5313829

CC(=O)OCc1oc(-c2n[nH]c3cccc(Cc4ccccc4)c23)nc1C

nearest known ligand 0.36

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 1/20 0.36
PPARD Q03181 9/20 0.35
VDR P11473 6/20 0.35
GPR84 Q9NQS5 2/20 0.35
FFAR1 O14842 1/20 0.34
MAPK1 P28482 2/20 0.33
MAP2K4 P45985 1/20 0.33
MAPKAPK2 P49137 1/20 0.33
MAPK6 Q16659 1/20 0.33
CYP1A2 P05177 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33
CYP2C9 P11712 1/20 0.33
CYP2C19 P33261 1/20 0.33
PTGS1 P23219 1/20 0.33
ESR1 P03372 1/20 0.33
THRA P10827 1/20 0.33
THRB P10828 1/20 0.33
RXRA P19793 1/20 0.33
PPARG P37231 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5314525 0.87 MAPK1 (0.34) PPARDVDRFFAR1MAPK1MAP2K4
SCHEMBL5430240 0.76 SMN1; SMN2 (0.42) ALDH1A1
SCHEMBL5314312 0.76 PPARD (0.34) PPARDVDRFFAR1MAPK1MAP2K4
SCHEMBL8470319 0.74 SMN1; SMN2 (0.35) ALDH1A1MAPK1CYP1A2CYP3A4CYP2D6
SCHEMBL8470520 0.72 CYP1A2 (0.39) ALDH1A1MAPK1MAP2K4MAPKAPK2MAPK6
SCHEMBL4425538 0.72 PPARD (0.53) ALDH1A1PPARDVDRFFAR1PTGS1
SCHEMBL5493286 0.71 KDM4E (0.41) ALDH1A1MAPK1CYP1A2CYP3A4CYP2D6
SCHEMBL8329288 0.69 PDE5A (0.40) ALDH1A1MAPK1MAP2K4MAPKAPK2MAPK6
SCHEMBL7497118 0.69 SMN1; SMN2 (0.48) ALDH1A1MAPK1MAP2K4MAPK6
SCHEMBL4424864 0.68 F2RL3 (0.52) ALDH1A1MAPK1CYP1A2CYP3A4CYP2D6

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007065010-A2 ANTI-ANGIOGENESIS COMPOUNDS HIF BIO, INC. (US) 2007-06-07 WO disclosed
EP-0934311-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER AG (DE) 1999-08-11 EP disclosed
WO-1998016507-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO disclosed