Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 8/20 | 0.47 |
| ▸ | HSD11B2 | P80365 | 3/20 | 0.45 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | MCHR2 | Q969V1 | 3/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | RBP4 | P02753 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314195 | 1.00 | HSD11B1 (0.47) | HSD11B1HSD11B2OPRD1KCNH2SIGMAR1 | |
| SCHEMBL9395018 | 0.80 | HSD11B1 (0.64) | HSD11B1HSD11B2OPRD1KCNH2RBP4 | |
| SCHEMBL9089853 | 0.75 | HSD11B1 (0.46) | HSD11B1HSD11B2KCNH2MCHR2 | |
| SCHEMBL14530315 | 0.75 | OPRD1 (0.35) | OPRD1SIGMAR1 | |
| SCHEMBL3710895 | 0.73 | HSD11B1 (0.44) | HSD11B1HSD11B2OPRD1KCNH2SIGMAR1 | |
| SCHEMBL3709006 | 0.73 | HSD11B1 (0.44) | HSD11B1HSD11B2OPRD1KCNH2 | |
| SCHEMBL1223122 | 0.72 | HSD11B1 (0.53) | HSD11B1HSD11B2OPRD1KCNH2 | |
| SCHEMBL1223056 | 0.72 | HSD11B1 (0.56) | HSD11B1HSD11B2OPRD1KCNH2SIGMAR1 | |
| SCHEMBL1223765 | 0.72 | HSD11B1 (0.56) | HSD11B1HSD11B2OPRD1KCNH2 | |
| SCHEMBL10771537 | 0.70 | HTR2C (0.36) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007057775-A1 | SPIROPIPERIDINE DERIVATIVES | PFIZER LIMITED (GB) | 2007-05-24 | — | — | WO | disclosed |