Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.68 |
| ▸ | MEN1 | O00255 | 2/20 | 0.68 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.68 |
| ▸ | APAF1 | O14727 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 1/20 | 0.68 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.68 |
| ▸ | HTT | P42858 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.68 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | FDPS | P14324 | 13/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17350737 | 0.98 | SMN1; SMN2 (0.65) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Hydrochloric Acid SCHEMBL28453551 | 0.96 | SMN1; SMN2 (0.62) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL530786 | 0.94 | SMN1; SMN2 (0.65) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| SCHEMBL24238633 | 0.92 | SMN1; SMN2 (0.61) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Hydrochloric Acid SCHEMBL28046617 | 0.90 | SMN1; SMN2 (0.59) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL29479434 | 0.90 | SMN1; SMN2 (0.81) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL29479433 | 0.88 | SMN1; SMN2 (0.85) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL18834186 | 0.88 | SMN1; SMN2 (0.85) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| Bromide SCHEMBL17395315 | 0.88 | SMN1; SMN2 (0.85) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 | |
| SCHEMBL9927858 | 0.88 | SMN1; SMN2 (0.77) | SMN1; SMN2MEN1HSP90AA1KMT2AAPAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415741-A1 | METHOD FOR PRODUCING ALCOHOL COMPOUND | Sumitomo Chemical Company, Limited (JP) | 2012-02-08 | — | — | EP | disclosed |
| US-20120010417-A1 | METHOD FOR PRODUCING ALCOHOL COMPOUND | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010417-A1 | METHOD FOR PRODUCING ALCOHOL COMPOUND | ADH1A, ADH1C, ADH5 | SMN1; SMN2 4595/4885MEN1 2392/4885HSP90AA1 1694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.