Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.54 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.46 |
| ▸ | CDK9 | P50750 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | JUN | P05412 | 2/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | STS | P08842 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313196 | 0.85 | ADORA2A (0.46) | MAPK8MAPK9CCNT1CDK2CCNA2 | |
| SCHEMBL8233028 | 0.82 | MAPK8 (0.62) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL8232786 | 0.82 | MAPK8 (0.58) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL5314464 | 0.82 | MAPK8 (0.56) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL8235073 | 0.81 | MAPK10 (0.61) | MAPK8MAPK9MAPK10CDK2CCNA2 | |
| SCHEMBL8232791 | 0.79 | MAPK8 (0.59) | MAPK8MAPK9MAPK10CCNT1CDK2 | |
| SCHEMBL8234082 | 0.76 | MAPK1 (0.40) | CCNT1CDK2CCNA2CDK9CCNA1 | |
| SCHEMBL14190850 | 0.76 | ADORA2A (0.56) | CDK2CCNA2ADORA2AGPR119USP30 | |
| SCHEMBL3650816 | 0.74 | HDAC8 (0.52) | MAPK8MAPK9MAPK10CDK2JUN | |
| SCHEMBL26120048 | 0.74 | ADORA2A (0.47) | MAPK8MAPK9MAPK10CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |