Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 5/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | TYK2 | P29597 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.30 |
| ▸ | CLK1 | P49759 | 1/20 | 0.30 |
| ▸ | CLK2 | P49760 | 1/20 | 0.30 |
| ▸ | CLK3 | P49761 | 1/20 | 0.30 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.30 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.30 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.30 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.30 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.30 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228313 | 0.77 | DYRK1A (0.54) | DYRK1AALDH1A1JAK2DYRK3CLK1 | |
| SCHEMBL8227604 | 0.76 | DYRK1A (0.41) | DYRK1AALDH1A1POLBJAK3SMN1; SMN2 | |
| SCHEMBL8233534 | 0.73 | CXCR4 (0.44) | DYRK1AMKNK2DYRK1BCDK2GSK3B | |
| SCHEMBL8233833 | 0.72 | DYRK1A (0.56) | DYRK1AMKNK2CDK2GSK3B | |
| SCHEMBL8234875 | 0.71 | DYRK1A (0.36) | DYRK1AALDH1A1POLBJAK2JAK1 | |
| SCHEMBL8234099 | 0.70 | DYRK1A (0.35) | DYRK1AALDH1A1POLBJAK3SMN1; SMN2 | |
| SCHEMBL5312173 | 0.70 | DYRK1A (0.36) | DYRK1AALDH1A1POLBJAK2JAK1 | |
| SCHEMBL8235675 | 0.69 | DYRK1A (0.45) | DYRK1AJAK2DYRK3CDK5CDK5R1 | |
| SCHEMBL8235923 | 0.69 | MKNK1 (0.43) | DYRK1AJAK2MKNK2DYRK1BCDK2 | |
| SCHEMBL8235083 | 0.67 | CDK2 (0.36) | DYRK1ADYRK3CDK5CDK5R1DYRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |