Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 9/20 | 0.36 |
| ▸ | GSK3B | P49841 | 3/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.32 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.32 |
| ▸ | CLK2 | P49760 | 2/20 | 0.32 |
| ▸ | CLK3 | P49761 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | CLK1 | P49759 | 1/20 | 0.32 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.32 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.32 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.32 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.32 |
| ▸ | DYRK4 | Q9NR20 | 1/20 | 0.32 |
| ▸ | STK39 | Q9UEW8 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228313 | 0.80 | DYRK1A (0.54) | DYRK1AGSK3BCDK4ALDH1A1CDK5 | |
| SCHEMBL8227604 | 0.79 | DYRK1A (0.41) | DYRK1AGSK3BALDH1A1POLBCDK5 | |
| SCHEMBL8233833 | 0.75 | DYRK1A (0.56) | DYRK1AGSK3BCDK4MKNK2CDK2 | |
| SCHEMBL5312173 | 0.73 | DYRK1A (0.36) | DYRK1AGSK3BALDH1A1POLBCDK5 | |
| SCHEMBL8234099 | 0.73 | DYRK1A (0.35) | DYRK1AGSK3BALDH1A1POLBCDK5 | |
| SCHEMBL5314533 | 0.71 | DYRK1A (0.34) | DYRK1AGSK3BALDH1A1POLBCDK5 | |
| SCHEMBL8233534 | 0.70 | CXCR4 (0.44) | DYRK1AGSK3BCDK4MKNK2DYRK1B | |
| SCHEMBL8235923 | 0.69 | MKNK1 (0.43) | DYRK1AGSK3BCDK4MKNK2DYRK1B | |
| SCHEMBL10520969 | 0.69 | TDO2 (0.47) | ALDH1A1POLBSMN1; SMN2GLA | |
| SCHEMBL8233943 | 0.69 | CDK4 (0.54) | DYRK1AGSK3BCDK4CDK2CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |