Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 10/20 | 0.41 |
| ▸ | DYRK1B | Q9Y463 | 4/20 | 0.41 |
| ▸ | CDK2 | P24941 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 2/20 | 0.35 |
| ▸ | CLK2 | P49760 | 2/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CLK3 | P49761 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8228313 | 0.85 | DYRK1A (0.54) | DYRK1ADYRK1BCDK2KDM4EALDH1A1 | |
| SCHEMBL8233833 | 0.80 | DYRK1A (0.56) | DYRK1ACDK2MKNK2GSK3B | |
| SCHEMBL8234875 | 0.79 | DYRK1A (0.36) | DYRK1ADYRK1BCDK2ALDH1A1POLB | |
| SCHEMBL16320863 | 0.78 | TGFBR1 (0.47) | DYRK1ADYRK1BCDK2KDM4ELMNA | |
| SCHEMBL8234099 | 0.78 | DYRK1A (0.35) | DYRK1ADYRK1BCDK2ALDH1A1POLB | |
| SCHEMBL5312173 | 0.78 | DYRK1A (0.36) | DYRK1ADYRK1BCDK2KDM4EALDH1A1 | |
| SCHEMBL16003806 | 0.76 | KDM4E (0.42) | DYRK1ADYRK1BCDK2KDM4ELMNA | |
| SCHEMBL5314533 | 0.76 | DYRK1A (0.34) | DYRK1ADYRK1BCDK2ALDH1A1POLB | |
| SCHEMBL8233534 | 0.75 | CXCR4 (0.44) | DYRK1ADYRK1BCDK2MKNK2GSK3B | |
| SCHEMBL8235923 | 0.74 | MKNK1 (0.43) | DYRK1ADYRK1BCDK2MKNK2GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |