Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 6/20 | 0.36 |
| ▸ | CDK4 | P11802 | 5/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.36 |
| ▸ | CDK1 | P06493 | 2/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.36 |
| ▸ | CCND3 | P30281 | 2/20 | 0.36 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 6/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.35 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8235675 | 0.88 | DYRK1A (0.45) | CDK2CDK4CCNA2CCNE1GSK3B | |
| SCHEMBL8233833 | 0.76 | DYRK1A (0.56) | CDK2CDK4GSK3BDYRK1AMKNK1 | |
| SCHEMBL8233534 | 0.73 | CXCR4 (0.44) | CDK2CDK4GSK3BDYRK1AMKNK1 | |
| SCHEMBL8235923 | 0.72 | MKNK1 (0.43) | CDK2CDK4GSK3BDYRK1AMKNK1 | |
| SCHEMBL8234846 | 0.70 | CDK4 (0.44) | CDK2CDK4CCNA2CDK1CCNE1 | |
| SCHEMBL8228313 | 0.70 | DYRK1A (0.54) | CDK2CDK4CCNA2CCNE1GSK3B | |
| SCHEMBL8237976 | 0.70 | DYRK1A (0.51) | CDK2CDK4CDK1GSK3BDYRK1A | |
| SCHEMBL8233943 | 0.69 | CDK4 (0.54) | CDK2CDK4CCNA2CDK1CCNE1 | |
| SCHEMBL8227604 | 0.69 | DYRK1A (0.41) | CDK2GSK3BDYRK1AMKNK2DYRK3 | |
| SCHEMBL5314566 | 0.68 | CDK4 (0.46) | CDK2CDK4CCNA2CDK1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |