SCHEMBL5314563

SCHEMBL5314563

C=C(C)C(=O)O[Si](C)(C)CCCCl

nearest known ligand 0.37

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.37
TSHR P16473 3/20 0.35
THRB P10828 1/20 0.32
POLB P06746 1/20 0.30
APEX1 P27695 1/20 0.30
HTT P42858 1/20 0.30
TDP1 Q9NUW8 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5838985 0.82 TSHR (0.48) ALDH1A1TSHRTHRB
SCHEMBL7185234 0.79 TSHR (0.55) ALDH1A1TSHRTHRB
SCHEMBL27941728 0.79 TSHR (0.55) ALDH1A1TSHRTHRB
SCHEMBL7185265 0.79 TSHR (0.55) ALDH1A1TSHRTHRB
SCHEMBL7507608 0.79 TSHR (0.55) ALDH1A1TSHRTHRBPOLBAPEX1
SCHEMBL2308683 0.78 TSHR (0.42) ALDH1A1TSHRTHRB
SCHEMBL8743897 0.75 TSHR (0.50) ALDH1A1TSHRTHRBPOLBAPEX1
SCHEMBL5832207 0.73 TSHR (0.51) ALDH1A1TSHRTHRBPOLBAPEX1
SCHEMBL15826448 0.73 TSHR (0.47) ALDH1A1TSHRTHRB
SCHEMBL5839559 0.73 ALDH1A1 (0.44) ALDH1A1TSHRTHRBTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1471069-B1 Preparation of silyl ketene acetals and disilyl ketene acetals SHINETSU CHEMICAL CO (JP) 2007-04-18 EP disclosed
EP-1471069-A1 Preparation of silyl ketene acetals and disilyl ketene acetals SHIN-ETSU CHEMICAL CO., LTD. (JP) 2004-10-27 EP disclosed