Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.47 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 3/20 | 0.45 |
| ▸ | DRD2 | P14416 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314851 | 0.95 | POLB (0.53) | KMT2APOLBPRKAA2DRD2DRD3 | |
| SCHEMBL5318355 | 0.91 | POLB (0.60) | KMT2APOLBMAPT | |
| SCHEMBL5315856 | 0.91 | POLB (0.49) | KMT2APOLBDRD2HTR1AHTR7 | |
| SCHEMBL5314874 | 0.90 | POLB (0.54) | KMT2APOLBSMN1; SMN2DRD2HTR1A | |
| SCHEMBL5317453 | 0.90 | KMT2A (0.48) | KMT2APOLBTP53SMN1; SMN2DRD2 | |
| SCHEMBL5315911 | 0.89 | POLB (0.46) | POLBTP53SMN1; SMN2 | |
| SCHEMBL5317191 | 0.86 | POLB (0.44) | KMT2APOLBSMN1; SMN2 | |
| SCHEMBL5336527 | 0.86 | KCNH2 (0.51) | KMT2APOLBSMN1; SMN2PRKAA2DRD2 | |
| SCHEMBL5315946 | 0.86 | KCNH2 (0.51) | KMT2APOLBSMN1; SMN2PRKAA2DRD2 | |
| SCHEMBL5316192 | 0.86 | HTT (0.52) | KMT2APOLBDRD2HTR1AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |