Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2964413 | 0.92 | KMT2A (0.52) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL17197367 | 0.87 | SMN1; SMN2 (0.52) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL224904 | 0.82 | ALDH1A1 (0.56) | KMT2AALDH1A1L3MBTL1MAPTLMNA | |
| SCHEMBL2969471 | 0.81 | ALDH1A1 (0.52) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL3534158 | 0.81 | RAB9A (0.56) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL657693 | 0.81 | CHEK1 (0.53) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL6377931 | 0.80 | KMT2A (0.57) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL1697621 | 0.80 | MAPT (0.67) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL5012954 | 0.79 | MAPT (0.45) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL22955262 | 0.79 | KMT2A (0.52) | KMT2ANPC1RAB9ASMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1836174-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC. (US) | 2007-09-26 | — | — | EP | disclosed |
| EP-1802586-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | Amgen Inc. (US) | 2007-07-04 | — | — | EP | disclosed |
| WO-2006044823-A2 | HETEROARYL-SUBSTITUTED ALKYNE COMPOUNDS AND METHOD OF USE | AMGEN INC. (US) | 2006-04-27 | — | — | WO | disclosed |
| WO-2006039718-A2 | ARYL NITROGEN-CONTAINING BICYCLIC COMPOUNDS AND THEIR USE AS KINASE INHIBITORS | AMGEN INC (US) | 2006-04-13 | — | — | WO | disclosed |