Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | ASIC3 | Q9UHC3 | 1/20 | 0.32 |
| ▸ | OGG1 | O15527 | 1/20 | 0.32 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | DHPS | P49366 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314553 | 0.80 | DHPS (0.44) | PARP1DHPSMAPTGRM2KDM4E | |
| Hydrochloric Acid SCHEMBL5656624 | 0.79 | DHPS (0.43) | PARP1DHPSMAPTGRM2KDM4E | |
| SCHEMBL5332356 | 0.78 | GRM2 (0.44) | HTR2AHTR2CMAPTGRM2KDM4E | |
| SCHEMBL5308823 | 0.76 | HTT (0.45) | PARP1HTR2AHTR2CMAPTALDH1A1 | |
| SCHEMBL5654201 | 0.74 | EGLN1 (0.47) | TP53MAPTHTR6KDM4EALDH1A1 | |
| SCHEMBL5655496 | 0.70 | DYRK1A (0.41) | PARP1HTR2AHTR2CHTR6CYP1A2 | |
| SCHEMBL5654278 | 0.68 | HTR2C (0.41) | PARP1HTR2AHTR2CHTR6CYP1A2 | |
| SCHEMBL5314950 | 0.66 | HTR2A (0.44) | HTR2AHTR2CDHPSGRM2HTR6 | |
| Hydrochloric Acid SCHEMBL5655466 | 0.65 | HTR2A (0.43) | HTR2AHTR2CDHPSGRM2HTR6 | |
| SCHEMBL1238170 | 0.65 | TNF (0.52) | PARP1HTR2AHTR2CMAPTHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070099912-A1 | Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | claimed |
| WO-2007053353-A2 | PYRROLO[2,3-F] AND [3,2-F]ISOQUINOLINONE DERIVATIVES AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2007-05-10 | — | — | WO | disclosed |
| US-20070099912-A1 | Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands | WYETH (US) | 2007-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070099912-A1 | Pyrrolo[2,3-F] and [3,2-F]Isoquinolinone derivatives as 5-hydroxytryptamine-6 ligands | HTR2C, HTR5A, HTR6 | LOXL2 2441/4885PARP1 2857/4885ASIC3 646/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.