Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 9/20 | 0.41 |
| ▸ | THRB | P10828 | 9/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PLEC | Q15149 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 1/20 | 0.35 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5359578 | 1.00 | THRA (0.41) | THRATHRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14540615 | 0.89 | THRA (0.42) | THRATHRBESR1NR3C1PGR | |
| SCHEMBL5309388 | 0.84 | THRA (0.39) | THRATHRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5309978 | 0.84 | THRA (0.39) | THRATHRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14540614 | 0.83 | THRA (0.38) | THRATHRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5309606 | 0.83 | THRA (0.38) | THRATHRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5310319 | 0.82 | THRA (0.37) | THRATHRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5310318 | 0.82 | THRA (0.37) | THRATHRBCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL4354616 | 0.76 | THRA (0.41) | THRATHRBALDH1A1GAAESR1 | |
| SCHEMBL4360479 | 0.76 | THRB (0.45) | THRATHRBCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007039125-A2 | AN OPTICALLY ACTIVE THYROID RECEPTOR AGONIST AND OPTICALLY ACTIVE KEY INTERMEDIATES IN ITS PRODUCTION | KARO BIO AB (SE) | 2007-04-12 | — | — | WO | disclosed |
| WO-2007039125-A2 | AN OPTICALLY ACTIVE THYROID RECEPTOR AGONIST AND OPTICALLY ACTIVE KEY INTERMEDIATES IN ITS PRODUCTION | KARO BIO AB (SE) | 2007-04-12 | — | — | WO | disclosed |