Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 11/20 | 0.76 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.76 |
| ▸ | CA2 | P00918 | 4/20 | 0.76 |
| ▸ | CA9 | Q16790 | 3/20 | 0.76 |
| ▸ | CA12 | O43570 | 2/20 | 0.76 |
| ▸ | S100B | P04271 | 1/20 | 0.62 |
| ▸ | FAAH | O00519 | 1/20 | 0.55 |
| ▸ | MGLL | Q99685 | 1/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.54 |
| ▸ | CA7 | P43166 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315002 | 1.00 | PTGS2 (0.76) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL11815957 | 0.89 | PTGS2 (0.78) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL5308961 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL5311501 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL1517619 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL5311504 | 0.86 | PTGS2 (1.00) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL10412841 | 0.85 | S100B (0.82) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL10733285 | 0.85 | S100B (0.82) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL12416630 | 0.85 | S100B (0.82) | PTGS2PTGS1CA2CA9CA12 | |
| SCHEMBL2010515 | 0.85 | S100B (0.82) | PTGS2PTGS1CA2CA9CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0799823-B1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | DAIICHI SANKYO CO LTD (JP) | 2007-10-31 | — | — | EP | disclosed |
| US-RE39420-E1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY, LIMITED (JP) | 2006-12-05 | — | — | US | disclosed |
| US-5908858-A | OSTEOPOROSIS; LEUKOTRIENE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |