Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.43 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CETP | P11597 | 2/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314874 | 0.87 | POLB (0.54) | POLBEPHX2SMN1; SMN2KMT2AHTR1A | |
| SCHEMBL5318125 | 0.85 | POLB (0.49) | POLBEPHX2SMN1; SMN2KMT2AHTR1A | |
| SCHEMBL3121813 | 0.85 | GPR119 (0.48) | NAMPTGPR119EGLN2SMN1; SMN2MEN1 | |
| SCHEMBL5316551 | 0.85 | POLB (0.48) | POLBEPHX2SMN1; SMN2MEN1KMT2A | |
| SCHEMBL3120225 | 0.84 | NAMPT (0.45) | NAMPTGPR119EGLN2EPHX2MEN1 | |
| Hydrochloric Acid SCHEMBL4667417 | 0.84 | GPR119 (0.47) | NAMPTGPR119EGLN2SMN1; SMN2MEN1 | |
| SCHEMBL5314851 | 0.82 | POLB (0.53) | POLBCYP2C19KMT2ADRD2HPGD | |
| SCHEMBL5316192 | 0.82 | HTT (0.52) | POLBMEN1KMT2AHTR1ADRD2 | |
| SCHEMBL5319733 | 0.81 | POLB (0.48) | POLBKMT2AHTR1ADRD2HPGD | |
| SCHEMBL2967666 | 0.80 | GPR119 (0.44) | NAMPTGPR119EGLN2CYP2C19HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |