Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 8/20 | 0.41 |
| ▸ | DRD3 | P35462 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 5/20 | 0.39 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317453 | 0.95 | KMT2A (0.48) | POLBKCNH2KCNJ1CA1CA2 | |
| SCHEMBL5316522 | 0.94 | POLB (0.43) | POLBKCNH2KCNJ1DRD2DRD3 | |
| SCHEMBL5314874 | 0.93 | POLB (0.54) | POLBCA12CA1CA2CA7 | |
| SCHEMBL5315892 | 0.93 | POLB (0.45) | POLBKCNH2KCNJ1CA12CA1 | |
| SCHEMBL5316699 | 0.92 | CA1 (0.44) | POLBKCNH2KCNJ1CA1CA2 | |
| SCHEMBL5331515 | 0.92 | LMNA (0.50) | POLBKCNH2CA1CA2CA7 | |
| SCHEMBL5315867 | 0.91 | ERCC1 (0.44) | POLBKCNH2KCNJ1DRD2DRD3 | |
| SCHEMBL5314570 | 0.90 | HTR1A (0.48) | POLBCA1CA2CA7DRD2 | |
| SCHEMBL5340709 | 0.90 | KCNH2 (0.41) | POLBKCNH2KCNJ1DRD2DRD3 | |
| SCHEMBL5314851 | 0.89 | POLB (0.53) | POLBCA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |