Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.58 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.58 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.58 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.58 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPY1R | P25929 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5132712 | 1.00 | CHRNB2 (0.58) | CHRNB2CHRNA5CHRNA7CHRNA4SPHK2 | |
| SCHEMBL3827589 | 0.91 | SPHK2 (0.66) | CHRNB2CHRNA5CHRNA7CHRNA4SPHK2 | |
| SCHEMBL4140738 | 0.89 | ABHD6 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL15811746 | 0.89 | ABHD6 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4NPC1 | |
| SCHEMBL5413716 | 0.88 | FFAR1 (0.55) | CHRNB2CHRNA5CHRNA7CHRNA4HRH3 | |
| SCHEMBL5318408 | 0.86 | CHRNB4 (0.53) | CHRNB2CHRNA5CHRNA7CHRNA4SPHK2 | |
| SCHEMBL5144697 | 0.85 | CHRNB2 (0.49) | CHRNB2CHRNA5CHRNA7CHRNA4SPHK2 | |
| SCHEMBL17008464 | 0.85 | ABHD6 (0.58) | NPC1RAB9A | |
| SCHEMBL4314170 | 0.85 | PRMT5 (0.56) | CHRNB2CHRNA5CHRNA7CHRNA4SPHK2 | |
| SCHEMBL4314700 | 0.85 | PRMT5 (0.56) | CHRNB2CHRNA5CHRNA7CHRNA4SPHK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007040681-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF (IS) | 2007-04-12 | — | — | WO | disclosed |