Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.49 |
| ▸ | CHRNA5 | P30532 | 1/20 | 0.49 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.49 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.49 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.46 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | STS | P08842 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.44 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | ABHD6 | Q9BV23 | 2/20 | 0.43 |
| ▸ | DAGLA | Q9Y4D2 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312768 | 0.86 | CHRNB2 (0.46) | CHRNB2CHRNA5CHRNA7CHRNA4HRH2 | |
| SCHEMBL13808960 | 0.86 | CHRNB2 (0.46) | CHRNB2CHRNA5CHRNA7CHRNA4HRH2 | |
| SCHEMBL5132712 | 0.85 | CHRNB2 (0.58) | CHRNB2CHRNA5CHRNA7CHRNA4SPHK2 | |
| SCHEMBL5315779 | 0.85 | CHRNB2 (0.58) | CHRNB2CHRNA5CHRNA7CHRNA4SPHK2 | |
| SCHEMBL15811746 | 0.85 | ABHD6 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4LTA4H | |
| SCHEMBL4140738 | 0.85 | ABHD6 (0.54) | CHRNB2CHRNA5CHRNA7CHRNA4LTA4H | |
| SCHEMBL5413716 | 0.84 | FFAR1 (0.55) | CHRNB2CHRNA5CHRNA7CHRNA4LTA4H | |
| SCHEMBL17008464 | 0.81 | ABHD6 (0.58) | LTA4HABHD6DAGLA | |
| SCHEMBL16468435 | 0.79 | LTA4H (0.49) | CHRNB2CHRNA7CHRNA4LTA4HPOLB | |
| SCHEMBL28159876 | 0.79 | FFAR1 (0.53) | CHRNB2CHRNA4LTA4HALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1926708-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | Decode Chemistry, Inc. (US) | 2008-06-04 | — | — | EP | disclosed |
| WO-2007040682-A1 | BIARYL SUBSTITUTED HETEROCYCLE INHIBITORS OF LTA4H FOR TREATING INFLAMMATION | DECODE GENETICS EHF. (IS) | 2007-04-12 | — | — | WO | disclosed |