Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.47 |
| ▸ | DRD2 | P14416 | 9/20 | 0.47 |
| ▸ | HTR7 | P34969 | 8/20 | 0.47 |
| ▸ | HTR6 | P50406 | 8/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | CCR5 | P51681 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | DRD1 | P21728 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD5 | P21918 | 1/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | HRH2 | P25021 | 1/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.40 |
| ▸ | HTR1B | P28222 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316269 | 0.95 | HTR1A (0.45) | HTR1ADRD2HTR7HTR6KCNH2 | |
| SCHEMBL5316850 | 0.92 | HTR1A (0.49) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL5319026 | 0.92 | HTR1A (0.49) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL5318113 | 0.91 | POLB (0.53) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL5314574 | 0.91 | KCNH2 (0.43) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL5315946 | 0.90 | KCNH2 (0.51) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL5336527 | 0.90 | KCNH2 (0.51) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL5315724 | 0.89 | KCNH2 (0.56) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL5317453 | 0.88 | KMT2A (0.48) | HTR1ADRD2HTR7HTR6KMT2A | |
| SCHEMBL5318523 | 0.88 | HTR1A (0.43) | HTR1ADRD2HTR7HTR6KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |