Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | HTR7 | P34969 | 7/20 | 0.43 |
| ▸ | HTR6 | P50406 | 7/20 | 0.43 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR3 | P51677 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAOB | P27338 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318523 | 0.92 | HTR1A (0.43) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5315933 | 0.91 | HTR1A (0.47) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5317494 | 0.90 | POLB (0.44) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5316850 | 0.90 | HTR1A (0.49) | HTR1ADRD2HTR7HTR6POLB | |
| SCHEMBL5319026 | 0.90 | HTR1A (0.49) | HTR1ADRD2HTR7HTR6POLB | |
| SCHEMBL5316269 | 0.90 | HTR1A (0.45) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5314630 | 0.87 | KCNH2 (0.55) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5314598 | 0.87 | KCNH2 (0.53) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5318113 | 0.85 | POLB (0.53) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5336527 | 0.83 | KCNH2 (0.51) | KCNH2HTR1ADRD2HTR7HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |