Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.47 |
| ▸ | KIF23 | Q02241 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5233894 | 0.89 | KIF11 (0.47) | KIF11KIF23NPSR1KDM4EMAPT | |
| SCHEMBL5232886 | 0.89 | KIF11 (0.51) | KIF11KIF23NPSR1KDM4EMAPT | |
| SCHEMBL3864873 | 0.89 | KIF11 (0.49) | KIF11KIF23NPSR1KDM4EMAPT | |
| SCHEMBL3869328 | 0.81 | MAPT (0.50) | KIF11KIF23NPSR1MAPTPDE4A | |
| SCHEMBL4883072 | 0.79 | KIF11 (0.41) | KIF11KIF23NPSR1KDM4EMAPT | |
| SCHEMBL4037664 | 0.78 | TP53 (0.41) | KIF11KIF23KDM4ETP53HPGD | |
| SCHEMBL5742317 | 0.78 | KIF11 (0.54) | KIF11KIF23NPSR1KDM4EMAPT | |
| SCHEMBL5742407 | 0.78 | PDE4A (0.46) | KIF11KIF23NPSR1KDM4EMAPT | |
| SCHEMBL5316065 | 0.78 | KIF11 (0.56) | KIF11KIF23NPSR1KDM4EMAPT | |
| SCHEMBL5316296 | 0.78 | MAPT (0.40) | KIF11KIF23KDM4EMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781673-A1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | AstraZeneca AB (SE) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006018627-A1 | SELECTED FUSED HETEROCYCLICS AND USES THEREOF | ASTRAZENECA AB (SE) | 2006-02-23 | — | — | WO | disclosed |