⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6488261 | 1.00 | — | — | |
| SCHEMBL30316733 | 1.00 | — | — | |
| SCHEMBL29240535 | 1.00 | — | — | |
| SCHEMBL12533533 | 0.98 | TSHR (0.43) | — | |
| SCHEMBL22263381 | 0.86 | ALDH1A1 (0.38) | — | |
| SCHEMBL31361158 | 0.85 | ALDH1A1 (0.37) | — | |
| SCHEMBL9065034 | 0.85 | HRH3 (0.38) | — | |
| Hydrochloric Acid SCHEMBL28248572 | 0.83 | HRH3 (0.37) | — | |
| SCHEMBL31111388 | 0.83 | HRH3 (0.43) | — | |
| SCHEMBL15321440 | 0.79 | DRD2 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 143 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7560474-B2 | Derivatives of pyridilethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, process for their preparation and pharmaceutical compositions containing them | LEK PHARMACEUTICALS D.D. (SI) | 2009-07-14 | — | — | US | claimed |
| US-20050256172-A1 | Novel derivatives of pyridilethanol (phenylethyl) amines as inhibitors of cholesterol biosynthesis, process for their preparation and pharmaceutical compositions containing them | LEK PHARMACEUTICALS D.D. (SI) | 2005-11-17 | — | — | US | claimed |
| EP-1546105-A1 | NOVEL DERIVATIVES OF PYRIDYLETHANOL (PHENYLETHYL) AMINES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Lek Pharmaceutical and Chemical Co. D.D. (SI) | 2005-06-29 | — | — | EP | claimed |
| WO-2004007456-A1 | NOVEL DERIVATIVES OF PYRIDYLETHANOL (PHENYLETHYL) AMINES AS INHIBITORS OF CHOLESTEROL BIOSYNTHESIS, PROCESSES FOR THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LEK PHARMACEUTICALS D.D. (SI) | 2004-01-22 | — | — | WO | claimed |
| EP-0302366-B1 | Substituted pyridine derivatives | BAYER AG (DE) | 1994-09-14 | — | — | EP | claimed |
| EP-0302366-A2 | Substituted pyridine derivatives | BAYER AG (DE) | 1989-02-08 | — | — | EP | claimed |
| US-12545684-B2 | CDK2 inhibitors | BLUEPRINT MEDICINES CORPORATION (US) | 2026-02-10 | — | — | US | disclosed |
| US-20240383902-A1 | CDK2 INHIBITORS | BLUEPRINT MEDICINES CORPORATION | 2024-11-21 | — | — | US | disclosed |
| CN-118265691-A | Cyclohexylbeta-hydroxyalkylamines and their medical use | 阿托基公司 | 2024-06-28 | — | — | CN | disclosed |
| EP-4363423-A1 | CDK2 INHIBITORS | Blueprint Medicines Corporation (US) | 2024-05-08 | — | — | EP | disclosed |
| US-11970498-B2 | CDK2 inhibitors | BLUEPRINT MEDICINES CORPORATION (US) | 2024-04-30 | — | — | US | disclosed |
| CN-117897384-A | CDK2 inhibitors | 缆图药品公司 | 2024-04-16 | — | — | CN | disclosed |
| US-11932648-B2 | CDK2 inhibitors | BLUEPRINT MEDICINES CORPORATION (US) | 2024-03-19 | — | — | US | disclosed |
| EP-0302366-A2 | Substituted pyridine derivatives | BAYER AG (DE) | 1989-02-08 | — | — | EP | disclosed |
| EP-0302366-A2 | Substituted pyridine derivatives | BAYER AG (DE) | 1989-02-08 | — | — | EP | disclosed |
| US-4800206-A | ANTIDIABETIC AGENTS; HYPOGLYCEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1989-01-24 | — | — | US | disclosed |
| EP-0254856-A2 | Pyridinethanol amine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1988-02-03 | — | — | EP | disclosed |
| EP-0194665-A1 | beta-Adrenergic receptor agonist alkylaminoalkyl pyridinemethanol derivatives | G.D. Searle & Co. (US) | 1986-09-17 | — | — | EP | disclosed |
| US-4600710-A | CARDIOTONIC, HYPOTENSIVE, VASODILATION | G. D. SEARLE & CO. (US) | 1986-07-15 | — | — | US | disclosed |
| US-4497964-A | CARBONYLATION, HYDROGENATION | SAGAMI CHEMICAL RESEARCH CENTER (JP) | 1985-02-05 | — | — | US | disclosed |