Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | IDH1 | O75874 | 7/20 | 0.40 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | IL6ST | P40189 | 1/20 | 0.36 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2199624 | 1.00 | RIPK1 (0.43) | RIPK1FAAHPOLBIDH1NAAA | |
| SCHEMBL2197865 | 1.00 | RIPK1 (0.43) | RIPK1FAAHPOLBIDH1NAAA | |
| SCHEMBL16228567 | 1.00 | RIPK1 (0.43) | RIPK1FAAHPOLBIDH1NAAA | |
| SCHEMBL2198920 | 1.00 | RIPK1 (0.43) | RIPK1FAAHPOLBIDH1NAAA | |
| SCHEMBL14548187 | 0.89 | FAAH (0.45) | FAAHIDH1NAAACSNK2BCSNK2A1 | |
| SCHEMBL13009264 | 0.87 | RIPK1 (0.42) | RIPK1FAAHPOLBIDH1DPP4 | |
| SCHEMBL13008579 | 0.87 | IDH1 (0.39) | RIPK1FAAHPOLBIDH1NAAA | |
| SCHEMBL4015233 | 0.84 | NAAA (0.42) | FAAHIDH1NAAACSNK2BCSNK2A1 | |
| SCHEMBL3940861 | 0.84 | NAAA (0.42) | FAAHIDH1NAAACSNK2BCSNK2A1 | |
| SCHEMBL3940865 | 0.84 | NAAA (0.42) | FAAHIDH1NAAACSNK2BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007068739-A1 | 4-AMINO-BENZAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |