Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | GBA1 | P04062 | 1/20 | 0.32 |
| ▸ | UBE2M | P61081 | 1/20 | 0.31 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.31 |
| ▸ | MLNR | O43193 | 1/20 | 0.31 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.30 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.30 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315253 | 1.00 | NCF1 (0.41) | NCF1CXCR4NAMPTHTR4HSD11B1 | |
| SCHEMBL416372 | 0.89 | NCF1 (0.43) | NCF1CXCR4HTR4ACHECHRM5 | |
| Hydrochloric Acid SCHEMBL5314906 | 0.87 | NCF1 (0.42) | NCF1CXCR4HTR4ACHECHRM5 | |
| SCHEMBL7226560 | 0.83 | NAMPT (0.36) | NAMPTHTR4HSD11B1TLR9TLR8 | |
| SCHEMBL5012467 | 0.83 | NAMPT (0.36) | NAMPTHTR4HSD11B1TLR9TLR8 | |
| SCHEMBL12671 | 0.80 | CHRM5 (0.52) | NAMPTHTR4HSD11B1TLR9TLR8 | |
| SCHEMBL8261146 | 0.79 | ACHE (0.55) | NAMPTHTR4HSD11B1TLR9TLR8 | |
| SCHEMBL13220 | 0.79 | ADRA2C (0.56) | NAMPTHTR4HSD11B1MGLLACHE | |
| SCHEMBL23015324 | 0.78 | NCF1 (0.52) | NCF1CXCR4ACHECHRM5ADRA2C | |
| SCHEMBL470130 | 0.77 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007068739-A1 | 4-AMINO-BENZAMIDE DERIVATIVES AS 5-HT4 RECEPTOR AGONISTS FOR THE TREATMENT OF GASTROINTESTINAL, NEUROLOGICAL AND CARDIOVASCULAR DISORDERS | GLAXO GROUP LIMITED (GB) | 2007-06-21 | — | — | WO | disclosed |