Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.51 |
| ▸ | ATF4 | P18848 | 4/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HRH2 | P25021 | 6/20 | 0.40 |
| ▸ | HRH1 | P35367 | 6/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | HTR6 | P50406 | 3/20 | 0.40 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.39 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.38 |
| ▸ | FLT1 | P17948 | 1/20 | 0.38 |
| ▸ | FLT4 | P35916 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5318102 | 0.91 | KCNH2 (0.52) | KCNH2POLBHRH2HRH1HRH3 | |
| SCHEMBL5315724 | 0.89 | KCNH2 (0.56) | KCNH2HRH2HRH1HRH3HTR1A | |
| SCHEMBL5314598 | 0.87 | KCNH2 (0.53) | KCNH2HRH2HRH1HRH3HTR1A | |
| SCHEMBL5336447 | 0.85 | KCNH2 (0.46) | KCNH2POLBHRH3HTR1ADRD2 | |
| SCHEMBL5316933 | 0.85 | KCNH2 (0.47) | KCNH2POLBHRH2HRH1HRH3 | |
| SCHEMBL5319103 | 0.85 | KCNH2 (0.49) | KCNH2HRH2HRH1HRH3HTR1A | |
| SCHEMBL5316196 | 0.85 | KCNH2 (0.48) | KCNH2POLBHRH2HRH1HRH3 | |
| SCHEMBL5336527 | 0.85 | KCNH2 (0.51) | KCNH2POLBHTR1ADRD2HTR7 | |
| SCHEMBL5315946 | 0.85 | KCNH2 (0.51) | KCNH2POLBHTR1ADRD2HTR7 | |
| SCHEMBL5314630 | 0.84 | KCNH2 (0.55) | KCNH2HRH2HRH1HRH3HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |