Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 8/20 | 0.45 |
| ▸ | DRD2 | P14416 | 8/20 | 0.45 |
| ▸ | HTR7 | P34969 | 5/20 | 0.45 |
| ▸ | HTR6 | P50406 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.45 |
| ▸ | HTR5A | P47898 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.44 |
| ▸ | HRH1 | P35367 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.44 |
| ▸ | CACNA1B | Q00975 | 4/20 | 0.44 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5319103 | 0.96 | KCNH2 (0.49) | KCNH2KCNA5HTR1ADRD2HTR7 | |
| SCHEMBL5314900 | 0.91 | KCNA5 (0.55) | KCNH2KCNA5HTR1ADRD2HTR7 | |
| SCHEMBL5315724 | 0.91 | KCNH2 (0.56) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5314598 | 0.90 | KCNH2 (0.53) | KCNH2KCNA5HTR1ADRD2HTR7 | |
| SCHEMBL5318090 | 0.90 | KCNH2 (0.52) | KCNH2KCNA5MEN1HRH2HRH1 | |
| SCHEMBL5315427 | 0.89 | MEN1 (0.47) | KCNH2KCNA5HTR1ADRD2HTR7 | |
| SCHEMBL5314570 | 0.89 | HTR1A (0.48) | HTR1ADRD2HTR7HTR6MEN1 | |
| SCHEMBL5314840 | 0.88 | HTR1A (0.53) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5315301 | 0.88 | KCNH2 (0.48) | KCNH2HTR1ADRD2HTR7HTR6 | |
| SCHEMBL5317348 | 0.88 | FAAH (0.46) | KCNH2MEN1HTR2AHRH3POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | claimed |
| WO-2007069986-A1 | NEW OXABISPIDINE COMPOUNDS FOR THE TREATMENT OF CARDIAC ARRHYTHMIAS | ASTRAZENECA AB (SE) | 2007-06-21 | — | — | WO | disclosed |