Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 9/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SGK1 | O00141 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914453 | 0.85 | ALDH1A1 (0.45) | PDE4BALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL12929707 | 0.73 | ALDH1A1 (0.66) | PDE4BALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5264668 | 0.72 | PDE4B (0.56) | PDE4BALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5914102 | 0.69 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL5265201 | 0.66 | PDE4B (0.60) | PDE4BALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4560197 | 0.65 | ALDH1A1 (0.63) | PDE4BALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL4669727 | 0.65 | MEN1 (0.54) | ALDH1A1SMN1; SMN2MEN1KMT2AMAPT | |
| Hydrochloric Acid SCHEMBL30227955 | 0.64 | PDE4B (0.51) | PDE4BALDH1A1SMN1; SMN2MEN1KMT2A | |
| SCHEMBL8294634 | 0.63 | ALDH1A1 (0.69) | ALDH1A1SMN1; SMN2MEN1KMT2AKDM4E | |
| SCHEMBL28103573 | 0.63 | PDE4B (0.77) | PDE4BALDH1A1MEN1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |