Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | BPTF | Q12830 | 1/20 | 0.35 |
| ▸ | KAT6A | Q92794 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 4/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA1 | P00915 | 2/20 | 0.34 |
| ▸ | CA2 | P00918 | 2/20 | 0.34 |
| ▸ | CA5A | P35218 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5914145 | 0.88 | IKBKB (0.37) | LMNATP53CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5914109 | 0.73 | MEN1 (0.41) | LMNATP53SMN1; SMN2MEN1RAB9A | |
| SCHEMBL5914113 | 0.71 | MEN1 (0.39) | LMNATP53CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4004337 | 0.71 | KDR (0.34) | LMNACYP3A4CYP2C9IKBKBMEN1 | |
| SCHEMBL5914156 | 0.69 | HTR7 (0.46) | KDRCDK2HTR2AHTR7 | |
| SCHEMBL20684698 | 0.67 | MEN1 (0.56) | TP53SMN1; SMN2MEN1RAB9AKMT2A | |
| SCHEMBL20684697 | 0.67 | MEN1 (0.60) | TP53SMN1; SMN2MEN1RAB9AKMT2A | |
| SCHEMBL4447801 | 0.65 | BPTF (0.54) | LMNATP53CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL19272769 | 0.64 | MEN1 (0.50) | TP53SMN1; SMN2MEN1RAB9AKMT2A | |
| SCHEMBL31206017 | 0.63 | CA12 (0.41) | LMNASMN1; SMN2RAB9ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794135-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | Amgen Inc. (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006037117-A1 | SUBSTITUTED HETEROCYCLIC COMPOUNDS AND METHODS OF USE | AMGEN INC. (US) | 2006-04-06 | — | — | WO | disclosed |